NYCOM Psychiatry Club

Taken entirely from www.schizophrenia.com:

1. Maternal infections during pregnancy are associated with increased risk of schizophrenia. Recent studies have indicated that children who born to mothers who suffer from flu, viruses and other infections during the pregnancy are at significantly increased risk of schizophrenia. A recent research study announced in April 2004 by Columbia University identified that approximately 14% of schizophrenia cases seem to have been caused by influenza during pregnancy.

The study indicated that Flu during the first trimester of pregnancy increased risk of developing schizophrenia in the child by approx. 700%, while flu during the third trimester increased schizophrenia risk for the child by 300%.

"This is the first time that this association has been shown using" blood tests that confirmed influenza infection during pregnancy, lead author Dr. Alan S. Brown, from Columbia University in New York, told Reuters Health. "It provides what I think is the strongest evidence to date linking (prenatal) influenza exposure with schizophrenia."

The findings reinforce recommendations that women of childbearing age be vaccinated against influenza, Brown continued. However, because the mechanism underlying the schizophrenia connection is unknown, "we may not want to give the vaccine during pregnancy," he said. Until more is known, "it's possible that vaccination (during pregnancy) could have a harmful effect."

Supporting Research (a sample):

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Flu During Pregnancy Linked to Schizophrenia (News, April'04)
• Flu During Pregnancy Triples Risk of Schizophrenia for child (News)
• Study links moms' herpes to schizophrenia in offspring (News)
• Prenatal exposure to influenza as a risk factor for adult schizophrenia. (Research)
• Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia. (Research)
• Exposure to prenatal infections, genetics and the risk of systematic and periodic catatonia
• In utero infection and adult schizophrenia (Research)
• Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. (Research)
• Maternal infections and subsequent psychosis among offspring (Research)
• Prenatal teratogens and the development of adult schizophrenia (Research)